Designed to provide the user with a literal new dimension in sample quality assessment and usher a new age in DNA quality control. Complete your analysis accurately from the start.

Typical electrophoresis-based DNA QC technologies can only provide information about the amount of DNA in a sample and the overall level of fragmentation of the molecules.

The BioCule platform, however, uses semi-denaturing conditions to analyze nucleic acids in two dimensions. This allows for the quantitation of the various sub-fractions of nucleic acids – dsDNA, ssDNA, DNA/RNA hybrids, inter- and intra-strand crosslinks, DNA nicks, etc.

Publications 

• Impact of different ChIP-Seq protocols on DNA integrity and quality of bioinformatics analysis results
  Briefings in Functional Genomics
   
• Importance of the Efficiency of Double-Stranded DNA Formation in cDNA Synthesis for the Imprecision of Microarray Expression Analysis
  Clinical Chemistry
   
• Two-dimensional strandness-dependent electrophoresis
  Nature Protocols
   
• Two-dimensional strandness-dependent electrophoresis: A method to characterize single-stranded DNA, double-stranded DNA, and RNA–DNA hybrids in complex samples
  Analytical Biochemistry
   
• Two-dimensional conformation-dependent electrophoresis (2D-CDE) to separate DNA fragments containing unmatched bulge from complex DNA samples 
  Nucleic Acids Research

Patents